Keyspan have just released their ER-V2 RF Remote for Windows Vista. Designed to be compatible with Vista's Media Center multimedia software, it provides more range, convenience and flexibility than infrared remotes.
The RF Remote for Windows Vista provides a range of up to 90 ft and does not require ‘line of sight’, so it will work from anywhere in your house (allegedly).
If you are setting up your own PC entertainment center, then this might be the remote for you.
Retail price is $49 but you can pick it up at Amazon for $39.50